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In children with SCD, baseline HbF remains the best predictor of drug-induced levels, but this accounts for only a portion of the induction.

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Obtaining specialty care can be a significant challenge as the number of health professionals trained to treat the disease is limited and the number of professionals specializing in the treatment of this disease is decreasing.

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STI stands for Signal Transduction Inhibitor and represents the action of the drug to inhibit enzymes called tyrosine kinase inhibitors.

we sought to determine if hydroxyurea therapy affects cell free dna

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Extended red blood cell (RBC) antigen matching is recommended to limit alloimmunization in patients with sickle cell disease (SCD).

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For more information, see "Transfusion Therapy" in Treatment section of this report.

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Phase III study to compare the efficacy and safety of the novel monopegylated interferon alpha 2b AOP2014 versus Hydroxyurea (the current licensed therapy for this disease).

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An 18-year-old female with sickle cell disease presented with thigh pain, dark urine, and hematuria within 72 hours of receiving a blood transfusion.

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