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Methotrexate may also cause lung damage or fertility problems and should not be taken by anyone with serious kidney or or by anyone who drinks alcohol.

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Intolerance to the sulfapyridine moiety of sulfasalazine is fairly common and may result in nausea, vomiting, dyspepsia, anorexia, and headache.

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Rate the appropriateness of initiating TNFα inhibitor in a patient with a history of arthritis of 5 or more joints who has received methotrexate for 6 months and has moderate disease activity and features of poor prognosis”).

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