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All participants had to have met criteria for a major depressive episode with a score of at least 15 on the Hamilton Depression Rating Scale (HAM-D).
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Mirtazapine enhances frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission by blockade of alpha2-adrenergic and serotonin2C receptors: a comparison with citalopram".
These beneficial effects appear to be mediated by various actions including 5HT 2 receptor blockade and action on presynaptic adrenergic alpha 2 receptors, on the HPA system, and on ghrelin and leptin.
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Eyding D, Lelgemann M, Grouven U, Härter M, Kromp M, Kaiser T, Kerekes MF, Gerken M, Wieseler B: Reboxetine for acute treatment of major depression: systematic review and meta-analysis of published and unpublished placebo and selective serotonin reuptake inhibitor controlled trials.
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The results of our review largely contradict the findings of previous systematic reviews and analyses of reboxetine versus placebo and reboxetine versus active comparators.
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